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The Resilience Project

Join the Search.  Be a Hero

The Resilience Project aims to discover hidden factors that protect people from disease.

Led by the Icahn Institute for Genomics at Mount Sinai, in collaboration with Sage Bionetworks and others worldwide, we are searching for people who, according to medical textbooks, should be sick but have somehow escaped typical signs and symptoms of disease.

These people are “resilient,” protected by undiscovered genetic or environmental factors. Finding and studying these resilient individuals could pave the way to disease prevention and new treatments.


Recently, we reported the first systematic search for resilience to hundreds of childhood diseases. The largest study of its kind, this retrospective study of more than 589,000 genomes was a key first step for the Resilience Project and was performed in collaboration with researchers from 23andMe, BGI, the Ontario Institute for Cancer Research, and other institutions. Click here to view the full study published in Nature Biotechnology in April 2016.

Perhaps you, or someone you know, are resilient to disease. With your help, we aim to expand the search for resilient individuals. By studying massive numbers of people for this rare trait, we hope to discover new insights that reduce the burden of disease.

Sign up for updates on the Resilience Project. We will let you know when we're accepting volunteers to join the search!

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Recent News

New York Times: People Who Avoided Illness Could Be Key in Treating Those Who Didn’t (4.11.16) Read here.
Nature: Superheroes of Disease Resistance (4.11.16) Read here.
NPR: How Do ‘Genetic Superheroes’ Overcome Their Bad DNA? (4.11.16) Read here.
BBC: ‘Superhero DNA’ Keeps Diseases at Bay (4.11.16) Read here.
PBS: These 13 Adults Escaped Deadly Genetic Childhood Disorders, but How? (4.11.16) Read here.
The Economist: The Genetic Superheroes Resistant to Inherited Fatal Diseases (4.11.16) Read here.
The Atlantic: Thirteen Anonymous Genetic Superheroes Walk Among Us (4.11.16) Read here.
MIT Technology Review: Search for New Medical Treatments Zeroes in on Genetic Superheroes (4.11.16) Read here.
Daily Mail: Are YOU a Genetic ‘Superhero?’ (4.11.16) Read here.
Science: ‘Buffer Genes’ May Protect These 13 People From Rare Genetic Diseases (4.11.16) Read here.
Mirror: Genetic Superheroes Could Bring Life-Saving Treatment to Millions (4.11.16) Read here.
U.S. News and World Report: Why Do Some Kids Escape Terrible Genetic Disorders? (4.11.16) Read here.
The Scientist: Genetic Resilience (4.11.16) Read here.